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T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th T-bet is cooperating with Stat4 signal tranducer and activator of transcription 4 in programming chromatin architecture for Th1 gene expression.
Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps. View more.
Advanced Verification. Online offer:. View reference. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue J Exp Med.
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. T-bet regulates IgG class switching and pathogenic autoantibody production.
Peng SL. The T-box transcription factor T-bet in immunity and autoimmunity. Cell Mol Immunol. A novel transcription factor, T-bet, directs Th1 lineage commitment.
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T-bet expression is optimally observed after IL stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL For flow cytometric staining, the suggested use of this reagent is 1.
It is recommended that the reagent be titrated for optimal performance for each application. Additional reported applications for the relevant formats include: immunoprecipitation 2 and immunofluorescence microscopy 3.
Szabo SJ, et al. Cell Science Finotto S, et al. Mullen AC, et al. For research use only. Not for diagnostic use. Not for resale.
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.